The necessarily mean steady state quantity of distribution (Vss) for sildenafil is one hundred and five L, indicating distribution into your tissues. Sildenafil and its significant circulating N-desmethyl metabolite are the two somewhere around ninety six% certain to plasma proteins. Protein binding is impartial of whole drug concentrations.
Your Health care company could recommend limiting or averting grapefruit while using sildenafil. Grapefruit or grapefruit juice can elevate sildenafil concentrations in Your system, which might enhance the danger of side effects.
Listening to: Scenarios of sudden decrease or loss of hearing are already claimed postmarketing in temporal association with the use of PDE5 inhibitors, which include VIAGRA. In a number of the circumstances, professional medical situations as well as other elements were noted that could have also performed a job from the otologic adverse occasions.
Viagra experienced no impact on saquinavir pharmacokinetics. A more powerful CYP3A4 inhibitor like ketoconazole or itraconazole may very well be envisioned to own greater influence than that seen with saquinavir. Population pharmacokinetic knowledge from sufferers in scientific trials also indicated a discount in sildenafil clearance when it had been co-administered with CYP3A4 inhibitors (including ketoconazole, erythromycin, or cimetidine) [see DOSAGE AND ADMINISTRATION and DRUG INTERACTIONS].
Snakk med lege før du tar legemidlet dersom du har høyt blodtrykk som ikke er godt behandlet, eller har uregelmessige hjerteslag/hjertebank.
nett (99+) apotek Dette produktet hentes i apotek ved bestilling på nett Legg til som favoritt
Tend not to consider sildenafil Until it's been prescribed to you personally by a healthcare provider. Just take it as prescribed.
VIAGRA was revealed to potentiate the hypotensive effects of nitrates and its administration in individuals who use nitric oxide donors which include organic and natural nitrates or natural nitrites in almost any kind is thus contraindicated [see CONTRAINDICATIONS, DRUG INTERACTIONS, and CLINICAL PHARMACOLOGY].
Serious coronary heart signs and symptoms for example rapid, irregular, or pounding heartbeats; fluttering in the upper body; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
Viagraprisen på en on the internet klinikk varierer fra klinikk til klinikk, men prisen er ca det dobbelte av prisen på et apotek hvor du selv kommer med en resept fra legen.
If you feel faint or dizzy, lie down. Notify your Health care service provider straight away if you have any of the next signs or symptoms of lower hypertension.
There is certainly a potential for cardiac hazard of sexual exercise in individuals with preexisting heart problems. Hence, treatment plans for erectile dysfunction, which include VIAGRA, shouldn't be frequently Utilized in website Guys for whom sexual exercise is inadvisable on account of their fundamental cardiovascular status.
If you take sildenafil When you consume a higher-Fats meal, for instance a burger and fries, it might take extended to start Doing the job.
VIAGRA may possibly influence the way in which other medicines function, along with other medicines might affect how VIAGRA operates producing Unintended effects. In particular tell your healthcare provider if you're taking any of the subsequent: